PCSK9 inhibitors: a major advance in cholesterol-lowering drug therapy

Every so often a medical advance comes along that rewrites the script for treating a disease or condition. After today‚Äôs announcements of impressive results of a new type of cholesterol-lowering drug, that scenario just might happen in the next few years. The new drugs, called PCSK9 inhibitors, are monoclonal antibodies. They target and inactivate a specific protein in the liver. Knocking out this protein, called proprotein convertase subtilisin kexin 9, dramatically reduces the amount of harmful LDL cholesterol circulating in the bloodstream. Lower LDL translates…

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